Assessing Genetic Expression Profiles in Melanoma Diagnosis

Low Expression of Occludin in the Melanoma Patient

Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in cancer, the prognostic signific...

Assessing Prognosis in Uveal Melanoma.

BACKGROUND Because uveal melanoma is the most common primary malignant intraocular tumor in adults and carries a significant risk of metastases, which are mostly unresponsive to available systemic therapy, researchers have been searching for prognostic indicators to identify patients at increased risk for developing such metastasis. METHODS The purpose of this study is to describe recent adva...

Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma

Genetic Network Reconstruction in Tryptophan Metabolism from Gene Expression Profiles

Tryptophan metabolism is one of the amino acid metabolisms that have been extensively studied. The extensive information on the genes, operons, and proteins for tryptophan biosynthesis and degradation and their regulatory mechanisms are known in diverse microorganisms, especially Escherichia coli [4, 5]. Here, the expression profiles of genes that were related with tryptophan metabolism in a pr...

Genetic diagnosis of cancer: diagnosis of mutations in BRCA1 and BRCA2 in breast cancer

During the last two decays the tremendous success in molecular biology and genetics which has surprised the entire world. So that today the sequencing of whole genome has been possible for each human individual to estimate its being affected with cardiovascular and cancer diseases. However, these achievements have some important limitations and deep ethical issues which might be ignored. Geneti...